Abstract: In order to improve the decoupling control performance of the practical technical processes, an intelligent cooperative decoupling controller (ICDC) based on the physiological regulation mechanism of blood pressure and body temperature is presented, and its control structure and decoupling algorithm are also provided. The ICDC is composed of the cooperative control unit (CCU), the control unit 1, and the control unit 2. Its decoupling algorithm is designed according to the idea of the cooperative decoupling. With the coordination of CCU, these two control units can work coordinately during the odd or even control periods. When one control unit is being in status of controlling, the other is being in that of decoupling. The simulation results demonstrate that the decoupling performance of ICDC is better than that of the conventional control solutions.