Abstract: An information security solution scheme of industrial control system based on trusted computing is proposed by taking into account the characteristics of information security of industrial control system and the technical features of existing defensive measures. By using the proposed linkage mechanism between the inside firewall of industrial control systems, the intrusion detection system and the trusted connection server, information interaction of network security devices is realized, which improves the overall defense capability of industrial control systems. Because of the protection pattern of trusted platform module based on hardware encryption, storage and control, the proposed solution overcomes the common shortcoming of the traditional pure software that is easily cracked, and this greatly increases security capacity of industrial control system. Finally, the trusted computing based information security solution for industrial control system is discussed by applying to the SCADA (supervisory control and data acquisition) system.