Abstract: Considering the problem of bidirectional parallel transmission of mobile agent (MA) in 3D space of wireless sensor networks, we propose a parallel mobile agent energy efficiency routing algorithm based on 3D cell space (3D-PEMA). We combines cell space model and data fusion model to judge whether MA performs data fusion when migrating to next node, and propose the data fusion judging distance. In single layer cell system, the algorithm optimizes routing strategy in horizontal plane based on bidirectional parallel MA routing algorithm (BPMA) with the combination of dispatching single MA and multiple MA. Simulation results show that compared with 3D-BPMA and multi-agent planning algorithm (MIP), 3D-PEMA algorithm effectively reduces the average energy consumption of network with fast response time, whosereliability is stronger.