Abstract: A well-designed space microgravity environment is important for microgravity science experiments. However, the actual microgravity acceleration level of space stations is far from ideal because of various disturbances. To address this problem, an active disturbance rejection control (ADRC) method is proposed based on a theoretical analysis of the structure, a dynamic model, and control objectives of the microgravity active vibration isolation system. Through the acceleration and position feedback along with the model compensation, the requirement for position control and vibration isolation is satisfied. Comparisons among numerical simulations demonstrate the superior performance of the proposed scheme.