Abstract: With the reference architecture model for Industries 4.0 (RAMI 4.0), smart manufacturing ecosystems, and the architecture for intelligent manufacturing systems proposed by Germany, the US, and China, respectively, an increasing number of studies have been focusing on the pyramid of enterprises. On the basis of the product life cycle, production life cycle, business cycle, and supply chain, a multi-dimensional value network for intelligent manufacturing is constructed, thereby providing a new perspective for positioning analysis of enterprises. As the core problem of modern enterprises' development, the transformation directions of functions, key technologies, and service patterns for the manufacturing execution system (MES) are analyzed in detail, thereby providing reference values for researchers, enterprises, and MES suppliers.