Abstract: Aiming at an industry cyber-physical system (ICPS) with limited energy denial of service (DoS) attack and actuator failure, we research the integrated safety control and communication codesign method. First, we construct a comprehensive security control architecture for the ICPS considering the DoS attack on one side of the network and formulate the corresponding energy grading standards by analyzing the impact of different energy levels of DoS attacks on the system from the perspective of the defender. Second, we design an energy level detection mechanism for DoS attacks, deal with low energy attacks through elastic control and robust response, and propose a proportional-differential (PD) data reconstruction compensation strategy for high energy attacks, which improves the active defense capability of ICPS against DoS attacks. The introduction of the security factor also encourages the principal and victim to move and attack to integrate and cooperate. Then, under the same nonuniform data transmission mechanism, we achieve the targets of active and passive mixed intrusion tolerance for DoS attacks of different energy levels, active fault tolerance of actuator failures, and codesign with communication through the given observer and integrated safety controller design method. Finally, we verify the effectiveness of the theoretical results via simulation of a four-capacity water tank system.