Abstract: For the dead-time and parameter uncertainties, a new improvement program of Smith prediction control system is presented based on the deduced parameter changes disturbance compensation formula of second-order system. Deadtime system control problem is effectively solved by this proposed method even in case that the mathematical model is unknown. The method includes simple structure and less tuning parameters, and it allows adjustment and realization easily.The simulation results show that this method has better adaptive capacity and robustness.