Abstract: For the problem of anti-jamming and time-delay output of the controlled system with long lag and large oscillation, an immune controller model for the single input single output(SISO) system is designed based on the similarity between the Varela immune network model and the controlled system.With the help of the controller,the stability of the augmented system and asymptotic tracking characteristics of the controlled system are obtained by means of the theory of nonlinear systems.Numerical experiments show that the controlled system can quickly track the given reference signal and has good anti-disturbance and anti-lag performances.