Abstract: Using the natural longevity Uygur people from Hetian area in China's Xinjiang Uygur Autonomous Region as examples,the research explores a new methodology of system modeling on bio-informatics system based on artificial intelligence(AI).Since artificial intelligence and data fusion techniques are introduced into the modeling process,the system is able to efficiently extract hidden information from large amount of uncoordinated individual biomedical data that is crucial to human longevity.We successfully establish an implicit non-verbal,non-mathematical AI natural longevity model,which not only behaves close to natural thinking,but also has such leading features as distinguishing and forecasting.This model can also be modified and transplanted.