Abstract: Based on a two-cell immune nonlinear feedback model and the characteristics of the control system,a two-cell artificial immune controller is designed,and its structure is given in this paper.Both theoretical research and simulation indicate that the system controlled with this immune controller can follow the invariable input without any error.Through simulations,the proposed immune control system is compared with the immune PID control system,and the simulation results show that the former is better than the latter in anti-delay,self-adaptation of object parameter change,etc.,and it is easy for the former to choose parameters.