Abstract: To solve the problems of nonlinearity, large time delay, and slow time-varying in the vertical roll mill grinding process, a generalized predictive proportional-integral-derivative controller (GPC-PID) is proposed, which shares the same structure with the traditional PID controller by constructing the weighted index of control in object function of GPC. The PID parameters are calculated based on the recursive relationship between the GPC and the PID algorithm. The simulation results show that the GPC-PID controller can stabilize the differential pressure well, and has the characteristics of fast response, high anti-interference and robustness.