Abstract: On the background of the project of CIMS application integration platform, this paper deeply studies the infrastructure and completion scheme of its operation management system(OMS), which acts as the system enable. Taking the advantage of the international research achievements on the software agent and workflow management, this paper proposes an agent supporting infrastructure in the distributed CIMS application integration environment, and an application cooperation model upon this structure based on WFMC’work. This paper uses the idea of software plug-ins to realize the design of OMS agents, and guarantees the open, reliable, and advanced properties of the OMS in CIMS application integration platform, by means of supplying correspondent agent APIs, workflow management APIs, and platform management tools.