Abstract: In this study on mechanical and electrical equipment signal disposal system fault self-healing, by analyzing the structure, parameters, and typical fault characteristics of signal disposal systems, we evaluate the system decay resistance after establishing a health factor group. By analyzing the biological immunity mechanism, we build a mapping relationship from the immune system to the self-healing system, a model of the fault self-healing system structure based on the immune principle, and introduce the main modules in the model structure and its algorithm. According to the fault self-healing model establishment method, we set up a signal conditioning system model and analyze the system failure. Simulation experiments are carried out to verify its feasibility and effectiveness and the results show that the fault self-healing system for signal disposal based on the immune principle can realize self-healing of the system's main faults.